Six-Week Open-Label Reboxetine Treatment in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Ratner S, Laor N, Bronstein Y, Weizman A, Toren P.
Drs. Ratner, Laor, Bronstein, and Toren are with the Tel Aviv-Brull Community Mental Health Center, Israel;
Dr. Weizman is with the Geha Mental Health Center and the Felsenstein Medical Research Center, Petah Tiqva, Israel;
Drs. Laor, Weizman, and Toren are with the Sackler Faculty of Medicine, Tel Aviv University;
Dr. Laor is with the Yale Child Study Center, New Haven, CT.
J Am Acad Child Adolesc Psychiatry. 2005 May;44(5):428-433


OBJECTIVE:: This open-label study assessed the effectiveness of reboxetine, a selective norepinephrine reuptake inhibitor, in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) resistant to a previous methylphenidate trial. METHOD:: Thirty-one child and adolescent outpatients, aged 8 to 18 (mean age, 11.7; SD = 2.87) years, diagnosed with ADHD were enrolled in a 6-week open-label study. Assessments included rater-administered scales (DSM-IV ADHD Scale; Clinical Global Impressions Scale), parent-administered scales (the Abbreviated Conners Rating Scale), and self-administered-scales for the evaluation of depressive (Children's Depression Inventory) and anxiety (the Revised Children's Manifest Anxiety Scale) symptoms. Reboxetine was initiated and maintained at a dose of 4 mg/day. RESULTS:: A significant decrease in ADHD symptoms, on all scales measured, was noted. Adverse effects were relatively mild and transient. The most common adverse effects were drowsiness/sedation and gastrointestinal complaints. CONCLUSIONS:: The results of the current open-label study suggest the effectiveness of reboxetine in the treatment of ADHD in methylphenidate-resistant children and adolescents. Double-blind, placebo-, and active comparator-controlled studies are indicated to rigorously test the efficacy of reboxetine in ADHD.

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