Superior safety of reboxetine over amitryptiline in the elderly
by
Agelink MW, Ullrich H, Passenberg P, Sayar K, Brockmeyer NH.
Dept. of Biological Psychiatry and Neuroscience,
Evangl. Clinics Gelsenkirchen, Ruhr-University of Bochum,
Munckelstr, Germany.
EurJMedRes@t-online.de .
Eur J Med Res 2002 Sep 30;7(9):415-6


ABSTRACT

Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhibitor, proceeded without complications.


Selectivity
Reboxetine
Venlafaxine
Noradrenaline
Amitriptyline (Elavil)
Serotonin reuptake inhibition
Dopamine reuptake inhibition
Noradrenaline reuptake inhibition



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