Tamsulosin as an effective treatment
for reboxetine-associated urinary hesitancy

by
Demyttenaere K, Huygens R, Van Buggenhout R.
Department of Psychiatry and
Institute for Familial and Sexological Sciences,
University Hospital Gasthuisberg, Leuven, Belgium.
koen.demyttenaere@med.kuleuven.ac.be
Int Clin Psychopharmacol 2001 Nov;16(6):353-5


ABSTRACT

Reboxetine, the only selective noradrenaline reuptake inhibitor, is an effective and well tolerated antidepressant. Although reboxetine has no anticholinergic effects, urinary hesitancy/retention is occasionally observed in male patients. A peripheral noradrenergic mechanism of action has been suggested as being responsible for this side-effect. To test this hypothesis, the alpha1A-receptor antagonist, tamsulosin, was administered to six male patients who developed urinary hesitancy in association with reboxetine treatment. The evolution of the severity of the urinary hesitancy was assessed using the American Urological Association (AUA) symptom index and a (dis)satisfaction item score. Tamsulosin (0.4 mg/day) rapidly ameliorated symptoms in all patients. After 1 week of tamsulosin treatment, total AUA symptom index score and the (dis)satisfaction item score had decreased significantly (P = 0.04 and P = 0.007, respectively). Furthermore, tamsulosin was well tolerated in all patients. These results suggest that tamsulosin is an effective treatment for reboxetine-associated urinary hesitancy.


Tamsulosin
NARIs and SSRIs
Urinary hesitancy
Reboxetine: structure
Reboxetine and the rat
Reboxetine and the elderly
Reboxetine versus fluoxetine
Reboxetine and major depression
Reboxetine and social functioning
Sexual function on reboxetine v paroxetine
Depression, antidepressants and noradrenaline


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